J. Chugh

Outer membrane proteins in Mycobacterium tuberculosis and its potential role in small molecule permeation

This study identifies outer membrane proteins in Mycobacterium tuberculosis involved in small molecule permeation, with potential applications for improving anti-TB drug efficacy.

Differential conformational dynamics in two type-A RNA-binding domains drive the double-stranded RNA recognition and binding

This study compares the conformational dynamics of two TRBP dsRBD domains, revealing differential binding affinities and structural plasticity in dsRNA recognition.

Characterization of conformational dynamics at microsecond timescale in the RNA-binding regions of dsRNA-binding domains

This study characterizes microsecond timescale conformational dynamics in RNA-binding regions of two dsRBDs using NMR, revealing similar dynamics that may aid in substrate recognition.

Role of protein dynamics in enthalpy-driven recognition of topologically distinct dsRNAs by dsRBDs

This study investigates how dsRBDs bind to various dsRNAs through enthalpy-driven interactions and intrinsic dynamics, showing conformational changes upon binding.

Cold storage reveals distinct metabolic perturbations in processing and non-processing cultivars of potato

The paper uses metabolomic profiling and bioinformatics to identify metabolite biomarkers and genes involved in cold-induced sweetening in potato cultivars.

NMR-based analysis of nucleotide π-stacking in a crowded environment: Implications for prebiotic reactions

This study uses NMR to analyze how molecular crowding affects purine and pyrimidine monomer stacking, suggesting crowding enhances purine stacking and may impact prebiotic polymerization.