S. Rajamani

Nucleotide-protocell interactions: A reciprocal relationship in prebiotically pertinent environments

This study investigates how nucleotides affect the properties of model protocellular membranes under prebiotically relevant conditions, finding that nucleotides can modulate membrane stability and aggregation behavior.

Effect of 'spent'nucleotides' on nonenzymatic RNA replication

This study investigates how spent ribonucleotides inhibit nonenzymatic RNA replication by interfering with base pairing and primer extension.

A prebiotic genetic alphabet as an early Darwinian ancestor for pre-RNA evolution

This study synthesizes a prebiotic genetic alphabet with barbituric acid and demonstrates its enzymatic incorporation into RNA and transfer to DNA, suggesting a pathway for early genetic code evolution.

TREK-1 knock-down in human atrial fibroblasts leads to a myofibroblastic phenotype: a role in phenoconversion and overview of mechano-sensitive channel mRNA expression in cardiac diseases.

Nonenzymatic template-directed replication using 2'-3' cyclic nucleotides under wet-dry cycles

This study demonstrates nonenzymatic template-directed RNA replication using 2'-3' cyclic nucleotides under wet-dry cycles at high temperature and alkaline conditions.

pH-responsive self-assembled compartments as tuneable model protocellular membrane systems

This study investigates pH-responsive self-assembly of amphiphiles to create model protocellular membranes with tunable properties.

Porphyrin in prebiotic catalysis: Ascertaining a route for the emergence of early metalloporphyrins

This study investigates how porphyrins influence metal ion-mediated prebiotic reactions, showing enhanced catalytic activity and substrate versatility in metal-porphyrin complexes.

Compositional heterogeneity confers selective advantage to protocellular membranes during the origins of cellular life

This study shows that compositional heterogeneity in protocellular membranes enhances their stability under multiple prebiotic selection pressures, making them more suitable for supporting early life.

Emergence of ribozyme and tRNA-like structures from mineral-rich muddy pools on prebiotic earth

This study models the emergence of ribozyme and tRNA-like structures from prebiotic environments through non-enzymatic polymerization and hydrolysis processes.

Geochemical influences on nonenzymatic oligomerization of prebiotically relevant cyclic nucleotides

This study investigates nonenzymatic oligomerization of cyclic nucleotides under prebiotically relevant conditions, showing that DH-RH cycles and amphiphiles promote RNA-like oligomer formation.

NMR-based analysis of nucleotide π-stacking in a crowded environment: Implications for prebiotic reactions

This study uses NMR to analyze how molecular crowding affects purine and pyrimidine monomer stacking, suggesting crowding enhances purine stacking and may impact prebiotic polymerization.