S. Patil

HOXA10 is a Temporal Switch in Controlling Decidual Inflammation and Its Dysregulation is Associated with Early Pregnancy Loss

This study identifies HOXA10 as a temporal switch regulating decidual inflammation, showing its dysregulation contributes to early pregnancy loss in mice and humans.

Array Detection Enables Large Localization Range for Simple and Robust MINFLUX

This paper introduces ISM-FLUX, a MINFLUX implementation using a SPAD array detector, achieving larger localization range and simpler architecture.

Preventing evolutionary rescue in cancer

This paper develops a theoretical framework to optimize cancer treatment scheduling by exploiting stochastic extinction of small tumors, showing that switching to a second treatment when the tumor is near its minimum size maximizes eradication probability.

Outer membrane proteins in Mycobacterium tuberculosis and its potential role in small molecule permeation

This study identifies outer membrane proteins in Mycobacterium tuberculosis involved in small molecule permeation, with potential applications for improving anti-TB drug efficacy.

Acvr1b loss increases formation of pancreatic precancerous lesions from acinar and ductal cells of origin

This study shows that Acvr1b loss in combination with Kras mutation promotes precancerous lesions from both acinar and ductal cells in the pancreas, but the IPMN-like phenotype differs when mutations occur in all cells.

Illuminating Dark Chemical Matter using the Cell Painting Assay

The paper uses the Cell Painting Assay to identify bioactive compounds in dark chemical matter, revealing modulators of microtubules, DNA synthesis, and pyrimidine biosynthesis.

Androgen Receptor driven gene score identifies tumors with Epithelial to Mesenchymal Transition features in triple negative breast cancer

The paper develops an AR-driven gene score to identify tumors with EMT features in triple-negative breast cancer, finding AR high tumors have better clinical outcomes and higher EMT marker expression.

BRCA1 expression, its correlation with clinicopathological features and response to neoadjuvant chemotherapy in high grade serous ovarian cancer from an Indian centre

Genome characterization of monkeypox cases detected in India: Identification of three sub clusters among A.2 lineage

The paper analyzes Monkeypox virus genomes from India, identifying three subclusters within the A.2 lineage and additional APOBEC3 mutations.

Impact of female mate copying on male morph dynamics

This study models how mate copying affects male morph dynamics in populations with multiple morphs and quantifies the copying level needed for stable equilibria.

Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation

An in vitro and in vivo approach for the isolation of Omicron variant from human clinical specimens

The paper isolates the Omicron variant from Syrian hamsters and compares its genetic changes to human clinical specimens and Vero CCL-81 cell passages.

Using Progressive Context Encoders for Anomaly Detection in Digital Pathology Images

A progressive context encoder trained only on normal skin whole slide images flags melanoma regions without manual tumor labels, reaching 89% pixel-level accuracy across 9 test slides.

Possible role of accessory proteins in the viral replication for the 20I/501Y.V1 (B.1.1.7) SARS-CoV-2 variant

The paper examines the replication cycle and transcriptional patterns of the B.1.1.7 SARS-CoV-2 variant, finding higher expression of ORF6 and ORF8 and increased infectivity despite lower copy numbers.

Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment

This study determines the crystal structure of the AnxA11 core, identifies a stabilizing N-terminal segment, and links three ALS mutations to conserved arginine residues critical for annexin folding.

Differential tissue stiffness of body column facilitates locomotion of Hydra on solid substrates

This study shows that differential tissue stiffness in Hydra's body column enables somersaulting locomotion on solid substrates, supported by mechanical measurements and computational models.

Assessing the in vitro resistance development in Enterovirus 71 in the context of combination antiviral treatment

This study evaluates how combining antivirals with different mechanisms delays resistance development in EV-A71 to pirodavir.

Direct Measurement of Dissipation in a Single Protein using Small Amplitude Atomic Force Microscopy

This paper measures dissipation in a single protein using small amplitude atomic force microscopy and finds internal friction scales with tension.