Author

J. Cools

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. Demeyer· 4 shared K. Jacobs· 3 shared D. Dierickx· 2 shared H. Segers· 2 shared L. Boogaerts· 2 shared M. Vanden Bempt· 2 shared N. Meeuws· 2 shared N. Mentens· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

S. Demeyer

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Author profile →

4 papers

Recent·Most cited

Dual targeting of EZH2 and Histone Deacetylases in hematological malignancies promotes transcriptional and metabolic deregulation leading to ferroptosis

A. Veloso, T. Slegers, J. Schoenaker, S. Demeyer, S. Van den Bergh, M. Aertgeerts, K. Verhoeft, Y. Schoenmaekers, N. Meeuws, I. Bischops, F. Renard, L. Boogaerts, N. Mentens, O. Gielen, K. Jacobs, , M. Vanden Bempt

This study shows that targeting EZH2 and HDACs together induces ferroptosis in hematological malignancies by upregulating cholesterol biosynthesis and causing metabolic stress.

bioRxiv · Mar 3, 2024 · PreprintCancer Biology

Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

C. Vandersmissen, S. Demeyer, K. Jacobs, L. Boogaerts, S. G. Fernandez, H. Segers, L. Chavez-Gutierrez, J. Cools

The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.

bioRxiv · Mar 1, 2024 · PreprintCancer Biology

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation

P. Altea-Manzano, G. Doglioni, A. M. Cuadros, E. Nolan, J. Fernandez-Garcia, Q. Wu, F. Cidre-Aranaz, A. Montagne, M. Planque, O. Marin-Bejar, J. Van Elsen, I. Vermeire, D. Broekaert, C. Riera-Domingo, F. Richard, , S.-M. Fendt

This study identifies palmitate-rich metastatic niches as promoters of metastasis by enhancing p65 acetylation and NF-κB signaling in breast cancer cells.

bioRxiv · Oct 24, 2022Cancer Biology

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T cell lymphoma

M. Vanden Bempt, K. Debackere, S. Demeyer, Q. Van Thillo, N. Meeuws, S. Provost, N. Mentens, K. Jacobs, O. Gielen, D. Nittner, S. Ogawa, K. Kataoka, C. Graux, T. Tousseyn, J. Cools, D. Dierickx

The paper identifies MYCN overexpression in PTCL and shows EZH2 as a transcriptional co-factor for MYCN-driven gene activation, with therapeutic implications for HDAC inhibitors.

bioRxiv · Mar 31, 2022Cancer Biology