Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques
K. Saunders, J. Counts, V. Stalls, R. Edwards, K. Manne, X. Lu, B. Thakur, K. Mansouri, Y. Chen, R. Parks, M. Barr, L. Sutherland, J. Bal, N. Havill, H. Chen, , B. F. Haynes
This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.
bioRxiv · Mar 5, 2023 · PreprintImmunology