L. Sutherland

Oxidative regulation of TDP-43 self-association by a beta-to-alpha conformational switch

This paper shows that oxidative modification of TDP-43's low complexity domain induces a beta-to-alpha conformational switch, disrupting self-association and phase separation.

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

Functional Anatomy of the TDP-43 Redox Sensor

This study investigates the role of individual hydrogen bonds in facilitating the self-adherence of the TDP-43 low complexity domain.

Tracing the genetics of neurological disease to the mutation-directed addition of single hydrogen bonds

The paper identifies recurrent mutations in low complexity domains that introduce single hydrogen bonds, and shows that methylation can restore normal protein function.

Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock

The paper uses stem cell-derived macrophages from livestock to study host-pathogen interactions, showing they can be infected by important viruses and genetically modified.

Dynamic structural order of a low complexity domain facilitates assembly of intermediate filaments

The paper shows that low complexity domains in Drosophila Tm1 proteins form labile cross-β interactions, facilitating intermediate filament assembly through dynamic structural transitions.

Transiently structured head domains control intermediate filament assembly

This study shows how low complexity head domains transiently form structured β-strand-enriched polymers that influence intermediate filament assembly and cell morphology.