Cancer BiologybioRxivPreprint
Pharmacologic Inhibition of DYRK1A Results in MYC Hyperactivation and ERK Hyperphosphorylation rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition
C. Hurtz, V. S. S. A. Ayyadevara, G. Wertheim…·S. K. Tasian
This study shows that inhibiting DYRK1A in KMT2A-R ALL cells leads to MYC upregulation and ERK hyperphosphorylation, making them sensitive to BCL2 inhibition.
DOI 10.1101/2022.10.02.510349