Author

G. Wertheim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

K. M. Bernt· 2 shared M. S. Lim· 2 shared S. K. Tasian· 2 shared A. De Martin· 1 shared A. Ferreira· 1 shared A. Kumar· 1 shared A. Lenard· 1 shared B. Austin· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

K. M. Bernt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Clonal evolution mediates Menin-inhibitor resistance in KMT2A-rearranged leukemias.

L. Mahdavi, H. Goodrow, F. Alikarami, A. Lenard, S. S. Riedel, C. Libbrecht, I. Bowser, S. K. Tasian, C. Falkenstein, B. Manning, S. Skuli, M. P. Carroll, G. Wertheim, S. Cai, G. McGeehan, , K. M. Bernt

This study shows that Menin-inhibitor resistance in KMT2A-rearranged leukemias arises through clonal evolution, with resistance developing without prior exposure to the inhibitor.

bioRxiv · Mar 16, 2023Cancer Biology

A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease

J. D. Brandstadter, A. De Martin, M. Lutge, A. Ferreira, B. T. Gaudette, Y. Stanossek, S. Wang, M. V. Gonzalez, E. Camiolo, G. Wertheim, B. Austin, D. Allman, M. S. Lim, D. C. Fajgenbaum, J. C. Aster, , I. Maillard

This study demonstrates that cryopreservation of lymphoid tissue allows for the study of non-hematopoietic stromal cells in human disease, preserving cell type proportions and transcriptional profiles.

bioRxiv · Feb 6, 2023Immunology

Pharmacologic Inhibition of DYRK1A Results in MYC Hyperactivation and ERK Hyperphosphorylation rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

C. Hurtz, V. S. S. A. Ayyadevara, G. Wertheim, J. Chukinas, J. P. Loftus, S. J. Lee, A. Kumar, R. S. Bhansali, S. Swaminathan, H. Geng, T. Milne, X. Hua, K. M. Bernt, T. Besson, J. Shi, , S. K. Tasian

This study shows that inhibiting DYRK1A in KMT2A-R ALL cells leads to MYC upregulation and ERK hyperphosphorylation, making them sensitive to BCL2 inhibition.

bioRxiv · Oct 2, 2022 · PreprintCancer Biology

Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells

F. MAURA, B. Ziccheddu, J. J. Xiang, B. Bhinder, F. Abascal, K. Maclachlan, K. W. Eng, M. Uppal, F. He, W. Zhang, Q. Gao, V. Yellapantula, S. Park, M. Oberley, E. Ruckdeschel, , L. Giulino-Roth

This study uses whole genome sequencing of Hodgkin and Reed Sternberg cells to reconstruct the temporal evolution of classic Hodgkin lymphoma, identifying key mutations and structural variants.

bioRxiv · Nov 5, 2021Cancer Biology