Cell BiologybioRxivPreprint
HECTD1 is both a positive regulator and substrate of caspase-3 activity during apoptotic cell death
N. Scholz, F. A. Siebzehnrubl, J. D. F. Licchesi
This study identifies HECTD1 as a caspase-3 substrate during apoptosis, showing cleavage does not affect its HECT domain function and suggests a feedback loop between caspase-3 and HECTD1.
DOI 10.1101/2023.02.17.528998