Pharmacology & ToxicologybioRxiv
Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation
S. R. Kuenzel, K. Sekeres, S. Kaemmerer…·A. El-Armouche
This study identifies hypoxia-induced epigenetic silencing of PLK2 and its role in promoting atrial fibrosis via OPN secretion in AF.
DOI 10.1161/circresaha.121.319425