Author

K. Guan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Plant Biology· 2 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:electrophysiology· 2 Organism:C. elegans· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

W. Li· 2 shared X. Luo· 2 shared A. El-Armouche· 1 shared A. Huang· 1 shared A. Sharma· 1 shared A. Strano· 1 shared A. Zhang· 1 shared C. Piorkowski· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersPharmacology & Toxicology

W. Li

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Comparative single-nucleus RNA-seq analysis captures shared and distinct responses to beneficial and pathogenic microbes in roots

Q. Yang, Z. Li, K. Guan, Z. Liu, A. Huang, J. Zhai, Y. Long, Y. Song

The paper uses single-nucleus RNA-seq to compare plant root responses to beneficial and pathogenic microbes, identifying triterpene biosynthesis as a novel response to pathogens.

bioRxiv · Aug 3, 2023 · PreprintPlant Biology

Effects of Hydroxychloroquine and Azithromycin on iPSC-derived Cardiomyocytes: Considerations for the Treatment of COVID-19 Patients

W. Li, X. Luo, M. S. Poetsch, R. Oertel, K. Nichani, M. Schneider, A. Strano, M. Hasse, R. P. Steiner, L. Cyganek, K. Hettwer, S. Uhlig, K. Simon, K. Guan, M. Schubert

This study investigates the effects of HCQ and AZM on iPSC-derived cardiomyocytes, finding that their combination significantly increases cardiotoxicity and electrophysiological dysfunction.

bioRxiv · Aug 19, 2021 · PreprintPharmacology & Toxicology

Blebbistatin protects iPSC-CMs from hypercontraction and facilitates automated patch-clamp based electrophysiological study

W. Li, X. Luo, Y. Ulbricht, K. Guan

This study shows that blebbistatin improves iPSC-CM quality during automated patch-clamp procedures, enabling reliable electrophysiological recordings and phenotyping of cardiac channelopathies.

bioRxiv · Jun 7, 2021Physiology

Discovery of photosynthesis genes through whole-genome sequencing of acetate-requiring mutants of Chlamydomonas reinhardtii

S. Wakao, P. M. Shih, K. Guan, W. Schackwitz, J. Ye, R. Shih, M. Chovatia, A. Sharma, J. Martin, C.-L. Wei, K. K. Niyogi

The paper sequenced genomes of photosynthesis mutants in Chlamydomonas reinhardtii to identify candidate genes involved in photosynthesis, validating two essential genes and uncovering 273 high-confidence candidates.

bioRxiv · Feb 17, 2021Plant Biology

Characterization of the gut DNA and RNA viromes in a cohort of Chinese residents and visiting Pakistanis

Q. Yan, Y. Wang, X. Chen, H. Jin, G. Wang, K. Guan, Y. Zhang, P. Zhang, T. Ayaz, Y. Liang, J. Wang, G. Cui, Y. Sun, M. Xiao, A. Zhang, , T. Ma

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

bioRxiv · Jul 28, 2020Microbiology

Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation

S. R. Kuenzel, K. Sekeres, S. Kaemmerer, T. Kolanowski, S. Meyer-Roxlau, C. Piorkowski, S. M. Tugtekin, S. Rose-John, X. Yin, M. Mayr, J. D. Kuhlmann, P. Wimberger, K. Gruetzmann, N. Herzog, J.-H. Kuepper, , A. El-Armouche

This study identifies hypoxia-induced epigenetic silencing of PLK2 and its role in promoting atrial fibrosis via OPN secretion in AF.

bioRxiv · Oct 17, 2018Pharmacology & Toxicology