Author

J. D. Shields

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Riedel· 2 shared B. Mahata· 2 shared G. Kar· 2 shared J. Pramanik· 2 shared S. A. Teichmann· 2 shared X. Chen· 2 shared C. P. Martins· 1 shared D. J. Adams· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

A. Riedel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

B. Mahata, J. Pramanik, L. v. d. Weyden, K. Polanski, G. Kar, A. Riedel, X. Chen, N. A. Fonseca, K. Kundu, L. S. Campos, E. Ryder, G. Duddy, I. Walczak, K. Okkenhaug, D. J. Adams, , S. A. Teichmann

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

bioRxiv · Jun 14, 2020Immunology

Stromal Amyloid β drives Neutrophil extracellular trap formation to augment tumour growth

H. Munir, J. O. Jones, T. Janowitz, C. P. Martins, S. P. Welsh, J. D. Shields

This paper identifies CAF-derived Amyloid β as a driver of tumor-induced NETosis, which promotes tumor growth and poor prognosis in human cancers.

bioRxiv · Jan 10, 2020 · PreprintCancer Biology

Podoplanin interaction with caveolin-1 promotes tumour cell migration and invasion

L. Pedro, J. D. Shields

The paper identifies a novel interaction between podoplanin and caveolin-1 that promotes melanoma cell migration and invasion through PAK1 and ERK1 pathways.

bioRxiv · Dec 6, 2018 · PreprintCancer Biology

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

S. Davidson, M. Efremova, A. Riedel, B. Mahata, J. Pramanik, J. Huuhtanen, G. Kar, R. Vento-Tormo, T. Hagai, X. Chen, M. A. Haniffa, J. D. Shields, S. A. Teichmann

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

bioRxiv · Nov 9, 2018 · PreprintCancer Biology