G. Kar

Rora regulates activated T helper cells during inflammation

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

The paper uses single-cell transcriptomics to identify novel cell states in healthy and asthmatic lung tissues, revealing changes in cell communication and immune responses.

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.