J. Daw

Seeding competent TDP-43 persists in human patient and mouse muscle

This study shows that TDP-43 aggregate seeds persist in both mouse and human skeletal muscle even after the removal of large TDP-43 inclusions.

Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy

This study shows that inhibiting DNAJ-HSP70 interaction improves muscle strength in LGMD1D by re-mobilizing HSP70 and correcting myopathology.