Author

J. Gestwicki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H. Shao· 3 shared A. Bhadra· 1 shared A. de la Pena· 1 shared A. Dillin· 1 shared A. Droop· 1 shared A. Dunn· 1 shared A. J. Davies· 1 shared A. L. Richards· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

H. Shao

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The YPhi Motif Defines the Structure-Activity Relationships of Human 20S Proteasome Activators

J. Gestwicki, K. Opoku-Nsiah, A. de la Pena, S. K. Williams, N. Chopra, A. Sali, G. Lander

The paper identifies the Y-F/Y (Y{Phi}) motif as the human 20S proteasome recognition sequence, revealing structural and functional differences from archaeal systems.

bioRxiv · Apr 28, 2021Biochemistry

Adhesion-mediated mechanosignaling forces mitohormesis

K. M. Tharp, R. Higuchi-Sanabria, G. Timblin, B. Ford, C. Garzon-Coral, C. Schneider, J. M. Muncie, C. Stashko, J. Daniele, A. S. Moore, P. Frankino, S. Manoli, H. Shao, A. L. Richards, K.-H. Chen, , V. M. Weaver

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

bioRxiv · Mar 6, 2020Cell Biology

Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy

R. Bengoechea, A. R. Findlay, A. Bhadra, H. Shao, K. Stein, S. K. Pittman, J. Daw, J. Gestwicki, H. True, C. C. Weihl

This study shows that inhibiting DNAJ-HSP70 interaction improves muscle strength in LGMD1D by re-mobilizing HSP70 and correcting myopathology.

bioRxiv · Jan 3, 2020Cell Biology

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

E. S. Polson, V. B. Kuchler, C. Abbosh, E. M. Ross, R. K. Mathew, H. A. Beard, E. Chuntharpursat-Bon, J. Williams, B. Da Silva, H. Shao, A. Patel, A. J. Davies, A. Droop, H. B. S. Griffiths, P. Chumas, , H. Wurdak

The paper shows KHS101 inhibits HSPD1 in glioblastoma cells, causing metabolic dysfunction and tumor growth reduction without affecting normal cells.

bioRxiv · Oct 18, 2017Cancer Biology