Author

J. Douglas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Biochemistry· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:statistical model· 3 Approach:deep learning· 2 Organism:human· 2 Research Focus:phylogenetics / evolution· 2 Research Focus:protein folding & dynamics· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

c. W. carter· 3 shared R. Bouckaert· 3 shared A. Henderson· 2 shared G. Q. Tang· 2 shared P. N. A. Harris· 2 shared P. R. Wills· 2 shared A. DeChellis· 1 shared A. J. Malik· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiochemistry

c. W. carter

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Author profile →

8 papers

Recent·Most cited

Genomic database furnishes a spontaneous example of a functional Class II glycyl-tRNA synthetase urzyme

S. K. Patra, J. Douglas, P. R. Wills, R. Bouckaert, L. Betts, G. Q. Tang, c. W. carter

The paper identifies a functional urzyme, GlyCA, from an arctic fox genome that exhibits enhanced catalytic activity compared to known urzymes, supporting the idea that urzymes represent ancestral catalytic activities in genetic coding.

bioRxiv · Jan 11, 2024 · PreprintEvolutionary Biology

Tertiary-interaction characters enable fast, model-based structural phylogenetics beyond the twilight zone

C. Puente-Lelievre, A. J. Malik, J. Douglas, D. Ascher, M. Baker, J. Allison, A. M. Poole, D. Lundin, M. Fullmer, R. Bouckaert, H. Kim, M. Steinegger, N. J. Matzke

This paper uses tertiary-interaction characters to improve structural phylogenetics beyond the twilight zone, achieving accurate results with fast computation.

bioRxiv · Dec 12, 2023 · PreprintEvolutionary Biology

HetMM: A Michaelis-Menten model for non-homogeneous enzyme mixtures

J. Douglas, C. W. Carter, P. R. Wills

HetMM introduces a kinetic model to analyze enzyme mixtures with heterogeneous catalytic activities, showing it outperforms the standard Michaelis-Menten model in both homogeneous and heterogeneous systems.

bioRxiv · Oct 10, 2023Biochemistry

Supercharging carbohydrate-binding module alone enhances endocellulase thermostability, binding, and activity on cellulosic biomass

A. DeChellis, B. Nemmaru, D. Sammond, J. Douglas, N. Patil, O. Reste, S. P. S. Chundawat

This study shows that supercharging carbohydrate-binding modules enhances endocellulase activity, thermostability, and performance on cellulosic biomass.

bioRxiv · Sep 9, 2023Bioengineering

Domain Acquisition by Class I Aminoacyl-tRNA Synthetase Urzymes Coordinated the Catalytic Functions of HVGH and KMSKS Motifs

G. Q. Tang, J. J. H. Elder, J. Douglas, C. W. Carter

This study examines the energetic coupling of catalytic motifs in LeuRS and its urzyme ancestor, showing how domain acquisition enhances transition-state stabilization.

bioRxiv · Apr 26, 2023Biochemistry

Quantitatively defining species boundaries with moreefficiency and more biological realism

J. Douglas, R. Bouckaert

This paper introduces a more efficient and biologically realistic species delimitation method using the multispecies coalescent model and validates it with genomic data.

bioRxiv · Feb 14, 2022Evolutionary Biology

Intensive infection control responses and whole genome sequencing to interrupt and resolve widespread transmission of OXA-181 Escherichia coli in a hospital setting

L. W. Roberts, B. M. Forde, A. Henderson, G. Playford, N. Runnegar, B. Henderson, C. Watson, M. Lindsay, E. Bursle, J. Douglas, D. L. Paterson, M. A. A. Schembri, P. N. A. Harris, S. A. Beatson

This study used whole genome sequencing to trace and control an outbreak of OXA-181-producing E. coli in a hospital, identifying its origin and transmission pathways.

bioRxiv · Nov 30, 2019 · PreprintMicrobiology

Prospective evaluation of beta-lactamase detection in penicillin susceptible Staphylococcus aureus by interpretation of the penicillin disc edge

A. Henderson, D. Whiley, F. Francis, C. Engler, M. Glover, J. Douglas, L. Gore, P. N. A. Harris, D. Paterson, G. R. Nimmo, R. Norton

The study evaluates the penicillin disc edge interpretation method for detecting blaZ in penicillin susceptible Staphylococcus aureus isolates, finding high sensitivity and specificity compared to PCR.

bioRxiv · Sep 26, 2019 · PreprintMicrobiology