M. Steinegger

Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

The paper identifies and validates four kynureninases using homology searches and protein language models, with the most active one showing significant tumor reduction in mouse models.

Tertiary-interaction characters enable fast, model-based structural phylogenetics beyond the twilight zone

This paper uses tertiary-interaction characters to improve structural phylogenetics beyond the twilight zone, achieving accurate results with fast computation.

Two-million-year-old microbial communities from the Kap Kobenhavn Formation in North Greenland

This paper reconstructs microbial communities from 2-million-year-old permafrost in Greenland, finding similarities to modern thawing permafrost microbes and suggesting microbial communities may signal climate change impacts before plants and animals.

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

This study identifies a novel LZTR1 variant causing cardiac hypertrophy by altering protein polymerization and ubiquitin ligase function, showing genetic correction can rescue the phenotype.

Beyond sequence similarity: cross-phyla protein annotation by structural prediction and alignment

This paper introduces MorF, a tool using structural similarity to annotate protein functions in sponges, improving annotation beyond sequence-based methods.

AGNOSTOS-DB: a resource to unlock the uncharted regions of the coding sequence space

AGNOSTOS-DB is a database that integrates known and unknown coding sequences from genomes and metagenomes to enhance understanding of genes of unknown function.

Unifying the known and unknown microbial coding sequence space

The paper presents a framework and workflow to integrate genes of unknown function into genomic analysis, quantifying their diversity and relevance across biomes and providing a resource for studying Cand. Patescibacteria.

Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping

This paper introduces cRASL-seq, a method for sensitive and high-throughput SARS-CoV-2 detection and genotyping without nucleic acid extraction or reverse transcription.

Metagenomic association analysis of gut symbiont Lactobacillus reuteri without host-specific genome isolation

This paper introduces a metagenomic approach to study host-specificity of Lactobacillus reuteri without genome isolation, showing consistent results with prior findings and novel associations in dogs.