C. Watson

Evolutionary dynamics in the decades preceding acute myeloid leukaemia

This study uses serial blood samples to analyze pre-cancerous evolutionary dynamics in acute myeloid leukaemia, showing how driver mutations accumulate and drive clonal expansion over decades.

Imputing Single-Cell Protein Abundance in Multiplex Tissue Imaging

This paper imputes single-cell protein abundance in multiplex tissue imaging data from a breast cancer cohort using machine learning, showing improved accuracy and biological relevance.

Biochemical and functional characterization of the p.A165T missense variant of mitochondrial amidoxime-reducing component 1 in HepG2 cells

This study characterizes the p.A165T missense variant of mARC1 in HepG2 cells, showing mislocalization, reduced stability, and impaired enzymatic function, which may explain its protective effect in liver disease.

Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers

This study creates a multimodal tumor atlas to analyze how metastatic HR+ breast cancers adapt to CDK4/6 inhibitors, revealing mechanisms like mTORC1 activation and immune microenvironment changes.

IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data

The paper introduces a new V allele naming scheme and genotype inference method for adaptive immune receptor sequencing, validated with genomic long read data and implemented in an R package.

Multiplexed microfluidic chip for cell co-culture

The paper introduces a microfluidic chip for co-culture studies that enables controlled paracrine signaling and high throughput.

Uncovering Xenobiotics in the Dark Metabolome using Ion Mobility Spectrometry, Mass Defect Analysis and Machine Learning

The paper develops a workflow combining ion mobility spectrometry, mass defect analysis, and machine learning to identify xenobiotics in metabolomic data, successfully annotating PFAS in human serum.

Intensive infection control responses and whole genome sequencing to interrupt and resolve widespread transmission of OXA-181 Escherichia coli in a hospital setting

This study used whole genome sequencing to trace and control an outbreak of OXA-181-producing E. coli in a hospital, identifying its origin and transmission pathways.

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.