Author

J. E. Choby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

D. S. Weiss· 2 shared A. J. Farrand· 1 shared A. P. Smith· 1 shared B. A. Berryhill· 1 shared B. R. R. Levin· 1 shared C. N. Abbott· 1 shared C. Nnabuife· 1 shared D. I. Andersson· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

D. S. Weiss

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Author profile →

3 papers

Recent·Most cited

Theoretical Considerations and Empirical Predictions of the Pharmaco- and Population Dynamics of Heteroresistance

B. R. R. Levin, B. A. Berryhill, T. Gil-Gil, J. A. Manuel, A. P. Smith, J. E. Choby, D. I. Andersson, D. S. Weiss, F. Baquero

This paper develops two mathematical models of heteroresistance to explore how resistance ascends and reverts during antibiotic treatment, showing that current identification methods are insufficient.

bioRxiv · Sep 21, 2023Microbiology

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

J. E. Choby, T. Ozturk, C. N. Abbott, C. Nnabuife, J. M. Colquhoun, S. W. Satola, P. N. Rather, T. Palzkill, D. S. Weiss

The paper shows how bacteria use copy number flexibility of ESBLs to develop heteroresistance to new antibiotics like cefiderocol, threatening beta-lactam effectiveness.

bioRxiv · Jun 7, 2022Microbiology

Molecular basis for the evolution of species-specific hemoglobin capture by pathogenic Staphylococcus

J. E. Choby, H. B. Buechi, A. J. Farrand, E. P. Skaar, M. F. Barber

The paper shows that hemoglobin evolution in primates affects bacterial iron acquisition by Staphylococcus aureus, with adaptive mutations impairing bacterial binding.

bioRxiv · Jun 7, 2018Microbiology