F. Baquero

The Tradeoffs Between Persistence and Mutation Rates at Sub-Inhibitory Antibiotic Concentrations in Staphylococcus aureus

This study examines how sub-inhibitory antibiotic concentrations affect mutation rates and persistence in Staphylococcus aureus, showing increased mutation rates and reduced persistence.

Bdellovibrio's Prey-Independent Growth is Fuelled by Amino Acids as a Carbon Source

This study shows Bdellovibrio bacteriovorus can grow without prey using amino acids as carbon sources, revealing their metabolic flexibility and potential for biotechnological applications.

The Evolution of Heteroresistance via Small Colony Variants in Escherichia coli Following Long Term Exposure to Bacteriostatic Antibiotics

This study shows that long-term exposure to bacteriostatic antibiotics in E. coli leads to the emergence of small colony variants (SCVs) that confer heteroresistance, which reverts upon antibiotic removal.

Long-term dynamics of the 'Serratia marcescens complex' in the hospital-built environment

The paper investigates the long-term dynamics of Serratia marcescens complex in hospital sinks, identifying persistent strains linked to outbreaks and revealing new insights into their ecology and resistance gene acquisition.

Theoretical Considerations and Empirical Predictions of the Pharmaco- and Population Dynamics of Heteroresistance

This paper develops two mathematical models of heteroresistance to explore how resistance ascends and reverts during antibiotic treatment, showing that current identification methods are insufficient.

What's the matter with MICs: The contribution of nutrients and limiting resources to the pharmacodynamics of antibiotics and bacteria

This study investigates how nutrient conditions affect antibiotic pharmacodynamics by comparing MICs and bacterial growth in rich and minimal media with E. coli and eight antibiotics.

A 21-year survey of Escherichia coli from bloodstream infections (BSIs) in a tertiary hospital reveals how community-hospital dynamics of the B2 phylogroup clones influence local BSI rates

This study analyzes 21 years of E. coli bloodstream infections in a hospital, showing how community and hospital dynamics of B2 phylogroup clones influence BSI rates.

Predation Efficiency upon Clinical Isolates: Bdellovibrio bacteriovorus is Prey Specific and Origin Dependent

This study evaluates the predation efficiency of Bdellovibrio bacteriovorus on clinical isolates of Serratia marcescens and Pseudomonas aeruginosa, finding that origin, not genetic background or antibiotic resistance, determines prey susceptibility.

Fitness cost of vancomycin-resistant Enterococcus faecium plasmids associated with hospital infection outbreaks

The paper analyzes the fitness cost and stability of vancomycin-resistant plasmids in Enterococcus faecium and E. faecalis, showing reduced host fitness and plasmid stability under selective pressure.

Simulating the Influence of Conjugative Plasmids Kinetic Values on the Multilevel Dynamics of Antimicrobial Resistance in a Membrane Computing Model

This paper simulates how plasmid kinetic values affect antimicrobial resistance dynamics in a membrane computing model, finding that conjugation rates and plasmid loss rates influence plasmid dominance and resistance gene spread.

Antibiotic killing of diversely generated populations of non-replicating bacteria

This study investigates antibiotic killing of three types of non-replicating bacterial populations and finds they are consistently killed by aminoglycosides and peptide antibiotics.

Reconstruction of Escherichia coli ancient diversification by layered phylogenomics and polymorphism fingerprinting

This paper uses layered phylogenomics and polymorphism fingerprinting to reconstruct the evolutionary history of Escherichia coli, identifying three root lineages and a new phylogroup, while highlighting adaptive strategies in different lineages.

Simulating multi-level dynamics of antimicrobial resistance in a membrane computing model

The paper uses a membrane computing model to simulate and analyze the multi-level dynamics of antimicrobial resistance across genes, clones, species, hosts, and environments.

In-Depth Resistome Analysis by Targeted Metagenomics

The paper introduces ResCap, a targeted metagenomics platform for analyzing resistomes, enhancing sensitivity and specificity in detecting antimicrobial resistance genes.