A. P. Smith

The Tradeoffs Between Persistence and Mutation Rates at Sub-Inhibitory Antibiotic Concentrations in Staphylococcus aureus

This study examines how sub-inhibitory antibiotic concentrations affect mutation rates and persistence in Staphylococcus aureus, showing increased mutation rates and reduced persistence.

The Evolution of Heteroresistance via Small Colony Variants in Escherichia coli Following Long Term Exposure to Bacteriostatic Antibiotics

This study shows that long-term exposure to bacteriostatic antibiotics in E. coli leads to the emergence of small colony variants (SCVs) that confer heteroresistance, which reverts upon antibiotic removal.

Theoretical Considerations and Empirical Predictions of the Pharmaco- and Population Dynamics of Heteroresistance

This paper develops two mathematical models of heteroresistance to explore how resistance ascends and reverts during antibiotic treatment, showing that current identification methods are insufficient.

What's the matter with MICs: The contribution of nutrients and limiting resources to the pharmacodynamics of antibiotics and bacteria

This study investigates how nutrient conditions affect antibiotic pharmacodynamics by comparing MICs and bacterial growth in rich and minimal media with E. coli and eight antibiotics.

Time-Dependent Increase in Susceptibility and Severity of Secondary Bacterial Infection during SARS-CoV-2 Infection

This study shows that SARS-CoV-2 infection increases susceptibility and severity of secondary bacterial infection in mice, with time-dependent effects on immune responses and lethality.

Multiple paths lead to salt tolerance - pre-adaptation vs dynamic responses from two closely related extremophytes

This study compares salt tolerance mechanisms in two extremophytes, showing they use distinct pathways to achieve similar adaptive traits.

Balancing growth amidst salinity stress-lifestyle perspectives from the extremophyte model Schrenkiella parvula

This study identifies key traits enabling Schrenkiella parvula to maintain growth and reproductive success under salt stress.

Dynamic pneumococcal genetic adaptations support bacterial growth and inflammation during coinfection with influenza

This study identifies bacterial genes critical for pneumococcal virulence and immune modulation during influenza coinfection using transposon mutagenesis and in vivo analysis.

COVID-19 virtual patient cohort reveals immune mechanisms driving disease outcomes

The paper develops a computational model of COVID-19 immunopathology to identify immune mechanisms driving severe disease outcomes.

Cross species multi-omics reveals cell wall sequestration and elevated global transcription as mechanisms of boron tolerance in plants

This study identifies mechanisms of boron tolerance in plants by comparing Arabidopsis thaliana and Schrenkiella parvula using multi-omics approaches, revealing cell wall sequestration and global transcriptional changes as key strategies.

Defining chromatin state transitions predicts a network that modulates cell wall remodeling in phosphate-starved rice shoots

The paper identifies chromatin state transitions in rice shoots under phosphate starvation that correlate with differentially expressed genes involved in cell wall remodeling.

A Critical, Nonlinear Threshold Dictates Bacterial Invasion and Initial Kinetics During Influenza

The paper identifies a nonlinear dose threshold for bacterial invasion during influenza, showing how virus-induced macrophage depletion affects bacterial growth kinetics.