Author

T. Palzkill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

C. Nnabuife· 2 shared A. Khalil· 1 shared A. Khan· 1 shared A. Q. Dinh· 1 shared A. Wanger· 1 shared B. Hanson· 1 shared C. A. Arias· 1 shared C. N. Abbott· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

C. Nnabuife

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors

S. A. Moghadasi, E. Heilmann, A. Khalil, C. Nnabuife, F. Kearns, C. Ye, S. N. Moraes, F. Costacurta, M. Esler, H. Aihara, D. von Laer, L. Martinez-Sobrido, T. Palzkill, R. E. Amaro, R. Harris

The paper identifies SARS-CoV-2 variants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing pre-existing resistance and potential for spread.

Science Advances · Mar 31, 2023Peer-reviewedMicrobiology

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

J. E. Choby, T. Ozturk, C. N. Abbott, C. Nnabuife, J. M. Colquhoun, S. W. Satola, P. N. Rather, T. Palzkill, D. S. Weiss

The paper shows how bacteria use copy number flexibility of ESBLs to develop heteroresistance to new antibiotics like cefiderocol, threatening beta-lactam effectiveness.

bioRxiv · Jun 7, 2022Microbiology

Extremely Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem GES Enzymes: A Newly Emerging Threat in the United States

A. Khan, T. T. Tran, R. Rios, B. Hanson, W. C. Shropshire, Z. Sun, L. Diaz, A. Q. Dinh, A. Wanger, L. Ostrosky-Zeichner, T. Palzkill, C. A. Arias, W. R. Miller

The paper identifies two U.S. clinical isolates of Pseudomonas aeruginosa ST309 resistant to carbapenems and beta-lactam/beta-lactamase inhibitor combinations, harboring tandem GES 19 and 26 enzymes, and reports successful treatment with ceftazidime/avibactam plus aztreonam.

bioRxiv · Jan 30, 2019Microbiology

Quantitative Real-Time Imaging of Glutathione with Sub-Cellular Resolution

X. Jiang, C. Zhang, J. Chen, S. Choi, Y. Zhou, M. Zhao, X. Song, X. Chen, M. Maletic-Savatic, T. Palzkill, D. Moore, M. C. Wang, J. Wang

This study develops a fluorescent probe to measure glutathione concentrations in the nucleus and cytosol, finding no significant concentration gradient between them.

bioRxiv · Jul 1, 2018Cell Biology