CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors.
H. Li, Y. Liu, C. N. Wilson, H. J. Bai, M. Jones, S. Wang, Y. Xiao, J. E. DeVore, E. Y. Maier, M. Boufraqech, U. Weyemi
The paper identifies ATM and KEAP1 as targetable vulnerabilities in solid tumors through a CRISPR metabolic screen revealing their synthetic lethality.
bioRxiv · May 3, 2022Cancer Biology