J. E. Irazoqui

This study shows that a glucose-fed microbiota in C. elegans reduces lifespan and healthspan, increases intestinal permeability, and raises susceptibility to bacterial pathogens.

This study identifies cryptic virulence and protective roles of individual CeMbio bacteria in C. elegans, highlighting the importance of HLH-30/TFEB in host defense.

This study identifies nhr-42 as a negative regulator of host defense genes in C. elegans, showing it limits immune response and reallocates energy resources post-infection.

This study identifies NHR-49/PPAR-α and HLH-30/TFEB as regulators of an infection-specific host response in C. elegans, revealing FMOs as innate immunity effectors.