Author

J. Eggert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. B. Au-Yeung· 3 shared K. Salaita· 2 shared A. J. Ross· 1 shared A. V. Kellner· 1 shared A. Weiss· 1 shared C. C. Porter· 1 shared C. D. Scharer· 1 shared C. J. Henry· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

B. B. Au-Yeung

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3 papers

Recent·Most cited

The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces

A. V. Kellner, R. Hunter, P. Do, J. Eggert, M. Jaffe, D. K. Geitgey, M. Lee, J. A. G. Hamilton, A. J. Ross, R. S. Ank, R. L. Bender, R. Ma, C. C. Porter, E. C. Dreaden, B. B. Au-Yeung, , K. Salaita

This study shows that the adipocyte niche impairs T-cell function by modulating cytoskeletal dynamics and reducing TCR-antigen forces in both mice and human T-cells.

bioRxiv · Jan 31, 2024 · PreprintBioengineering

Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness

J. Eggert, W. Zinzow-Kramer, Y. Hu, Y.-L. Tsai, A. Weiss, K. Salaita, C. Scharer, B. B. Au-Yeung

The study shows that prolonged TCR signaling from self-antigens in naive CD8 T cells reduces their responsiveness to foreign antigens through gene expression changes and negative regulators like Sts1 and Cbl-b.

bioRxiv · Jan 27, 2023Immunology

Strong basal/tonic TCR signals are associated with negative regulation of naive CD4+ T cells

W. M. Zinzow-Kramer, J. Eggert, C. D. Scharer, B. B. Au-Yeung

The paper investigates the relationship between strong tonic TCR signals and negative regulation in naive CD4+ T cells, finding that high tonic signals correlate with hypo-responsiveness and increased expression of negative regulators.

bioRxiv · Apr 20, 2022Immunology