Author

A. V. Kellner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

K. Salaita· 3 shared R. L. Bender· 2 shared A. J. Ross· 1 shared A. Velusamy· 1 shared B. B. Au-Yeung· 1 shared C. C. Porter· 1 shared C. J. Henry· 1 shared C. Zhu· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

K. Salaita

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mechanical force regulates ligand binding and function of PD-1

K. Li, P. Cardenas-Lizana, A. V. Kellner, Z. Yuan, E. Ahn, J. Lyu, Z. Li, K. Salaita, R. Ahmed, C. Zhu

This study shows mechanical force is critical for PD-1 function, as soluble PD-L1 lacks the mechanical support needed to trigger PD-1 signaling.

Nature Communications · Sep 27, 2024Peer-reviewedImmunology

The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces

A. V. Kellner, R. Hunter, P. Do, J. Eggert, M. Jaffe, D. K. Geitgey, M. Lee, J. A. G. Hamilton, A. J. Ross, R. S. Ank, R. L. Bender, R. Ma, C. C. Porter, E. C. Dreaden, B. B. Au-Yeung, , K. Salaita

This study shows that the adipocyte niche impairs T-cell function by modulating cytoskeletal dynamics and reducing TCR-antigen forces in both mice and human T-cells.

bioRxiv · Jan 31, 2024 · PreprintBioengineering

Unbreakable DNA tension probes show that cell adhesion receptors detect the molecular force-extension curve of their ligands

R. L. Bender, H. Ogasawara, A. V. Kellner, A. Velusamy, K. Salaita

The paper demonstrates that integrin receptors detect the molecular force-extension curve of their ligands, not just the magnitude of force.

bioRxiv · Apr 4, 2022 · PreprintBiophysics