A. Lu

TIR domains produce histidine-ADPR conjugates as immune signaling molecules in bacteria

The paper identifies His-ADPR as a novel TIR-derived immune signaling molecule in bacteria, showing its role in phage defense and structural basis for recognition.

Proliferating cell nuclear antigen involves in temperature stress tolerance of Ulva prolifera

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

Tissue-specific sex difference in mouse eye and brain metabolome under fed and fasted states

This study identifies tissue-specific and state-dependent sex differences in metabolomes of mouse eye and brain tissues under fed and fasted conditions.

Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

The paper identifies Tad1 proteins as inhibitors of TIR-domain signaling in bacterial antiphage systems, revealing gcADPR as the immune signaling molecule and its sequestration by Tad1.

Maternal effects on early-life gut microbiome maturation in a wild nonhuman primate

This study examines how maternal effects influence gut microbiome maturation in wild gelada infants during their first three years, showing differences in microbial composition between infants of first-time and experienced mothers.

NGF-p75 signaling coordinates skeletal cell migration during bone repair

This study identifies NGF-p75 signaling as critical for coordinating skeletal cell migration during bone repair by affecting osteogenic precursor migration and bone healing.

Early life gut microbiome dynamics mediate maternal effects of infant growth in vervet monkeys

This study shows that early life gut microbiome dynamics, particularly reduced alpha diversity and B. fragilis abundance, mediate maternal parity effects on infant growth in vervet monkeys.

CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

Two CRISPR screens identify SNX13 as a negative regulator of lysosomal cholesterol export, revealing its role in modifying NPC1 function and lipid homeostasis.

Counting of Enzymatically Amplified Affinity Reactions in Hydrogel Particle-Templated Drops

This paper presents a method to digitally count enzymatic reactions using hydrogel particle-templated drops, achieving femtomolar detection with standard equipment.

The Goldilocks Effect: Female geladas in mid-sized groups have higher fitness

The paper shows that female geladas in mid-sized groups have higher fitness due to lower infant mortality and infanticide from immigrant males.

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

Male-mediated maturation in a wild primate

The paper investigates male-mediated maturation in wild geladas, finding that exposure to novel males induces estrogen surges and affects female puberty timing.

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

The paper investigates the role of inter-domain dynamics in cholesterol transport by NPC1 and NPC1L1 proteins, showing that domain movement is essential and that Ezetimibe inhibits NPC1L1 by binding to multiple domains.

A Clostridia-rich microbiota contributes to increased excretion of bile acids in diarrhea-predominant irritable bowel syndrome

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

Glycosylation of gigaxonin regulates intermediate filaments: Novel molecular insights into giant axonal neuropathy

This study identifies O-GlcNAcylation of gigaxonin as a regulatory mechanism linking metabolism to intermediate filament proteostasis, offering insights into giant axonal neuropathy.

Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis

This study shows that PLEKHO1 in osteoblasts worsens joint inflammation in RA and promotes bone formation, suggesting it as a therapeutic target.