Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135
J. Gonzalez-Martinez, A. Cwersch, D. Martinez-Alonso, L. R. Lopez, J. Almagro, D. Megias, J. Boskovic, J. Gilabert, O. Grana Castro, A. Pierani, A. Behrens, S. Ortega, M. Malumbres
This study shows that Cep135 loss causes microcephaly in mice through p53-independent mechanisms due to neural progenitor adaptation failure to centriole defects.
bioRxiv · May 7, 2020 · PreprintCell Biology