M. Malumbres

PP2A-B55alpha,delta phosphatase counteracts Ki67-dependent chromosome individualization during mitosis

The paper identifies PP2A-B55alpha,delta phosphatase as counteracting Ki67-dependent chromosome individualization during mitosis in mice.

miR-203 drives breast cancer cell differentiation

This study shows that miR-203 promotes differentiation of breast cancer cells, reduces their self-renewal and growth, and suggests it as a potential therapeutic tool.

Bilallelic germline mutations in MAD1L1 induce a novel syndrome of aneuploidy with high tumor susceptibility

This study identifies biallelic MAD1L1 mutations causing aneuploidy and high tumor susceptibility, with systemic inflammation and clonal expansions observed in patient blood cells.

Haspin participates in Aurora phosphorylation at centromeres and contributes to chromosome congression in male mouse meiosis

This study investigates the role of Haspin in male mouse meiosis, showing its necessity for chromosome congression and Aurora B phosphorylation at centromeres.

A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner

This study identifies a cell cycle kinase-phosphatase module that restrains PI3K-Akt activity through mTORC1-dependent phosphorylation of IRS1 and GRB10.

miR-203 imposes an intrinsic barrier during cellular reprogramming by targeting NFATC2

This study identifies miR-203 as an intrinsic barrier to cellular reprogramming by repressing NFATC2, showing that its removal enhances reprogramming efficiency.

Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135

This study shows that Cep135 loss causes microcephaly in mice through p53-independent mechanisms due to neural progenitor adaptation failure to centriole defects.

A novel microRNA-based strategy to expand the differentiation potency of stem cells

This study shows that transient exposure to miR-203 enhances the differentiation capacity of murine and human PSCs by reversing DNA methylation.

Plk1 overexpression suppresses tumor development by inducing chromosomal instability

This study shows that Plk1 overexpression suppresses tumor development by causing chromosomal instability and cytokinesis defects, despite its role as an oncogene.

Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1

This study identifies cell cycle-dependent phosphorylation sites on human Cdc14A by Cdk1 and shows that phosphorylation modulates protein interactions rather than catalytic activity.