Cell BiologybioRxivPreprint
A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner
B. Sanz-Castillo, B. Hurtado, A. El Bakkali…·M. Malumbres
This study identifies a cell cycle kinase-phosphatase module that restrains PI3K-Akt activity through mTORC1-dependent phosphorylation of IRS1 and GRB10.