Activation of Notch1 drives the development of radiation-induced thymic lymphoma in p53 wild-type mice
C.-L. Lee, K. D. Brock, S. Hasapis, D. Zhang, A. B. Sibley, X. Qin, J. Gresham, I. Caraballo, L. Luo, A. R. Daniel, M. J. Hilton, K. Owzar, D. G. Kirsch
This study identifies Notch1 activation as a key driver of radiation-induced thymic lymphoma in p53 wild-type mice through genomic and functional analyses.
bioRxiv · Aug 21, 2020 · PreprintCancer Biology