K. Owzar

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.

The paper analyzes molecular differences in ductal carcinoma in situ (DCIS) by self-reported race and outcome groups, identifying variations in gene expression, tumor microenvironment, and copy number variations between Black and White women.

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHD

This study uses scRNA-Seq to analyze B cells from allo-HCT patients, revealing molecular differences in B cell subsets associated with active versus non-active cGVHD.

Comparative analysis of RNA enrichment methods for preparation of Cryptococcus neoformans RNA sequencing libraries

This paper compares three RNA enrichment methods for RNA-Seq in Cryptococcus neoformans, finding that RNase H depletion outperforms others in rRNA removal and expression accuracy.

APOBEC mutagenesis inhibits breast cancer growth through induction of a T cell-mediated antitumor immune response

This study shows that APOBEC mutagenesis in breast cancer promotes T cell-mediated antitumor immunity, leading to tumor growth inhibition and sensitivity to checkpoint inhibitors.

Activation of Notch1 drives the development of radiation-induced thymic lymphoma in p53 wild-type mice

This study identifies Notch1 activation as a key driver of radiation-induced thymic lymphoma in p53 wild-type mice through genomic and functional analyses.

Adaptation and Selection Shape Clonal Evolution During Residual Disease and Recurrence

This study tracks clonal evolution in residual breast cancer tumors and finds that recurrence can arise through distinct evolutionary paths with different clonal compositions and drug sensitivities.

A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.