Author

A. Leduc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Cell Biology· 1 Ecology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Assay:proteomics· 4 Research Focus:clustering· 3 Approach:experimental assay· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

N. Slavov· 5 shared A. A. Petelski· 2 shared D. H. Perlman· 2 shared E. Emmott· 2 shared H. Specht· 2 shared L. Khoury· 2 shared R. G. Huffman· 2 shared A. Biju· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersBioengineering

N. Slavov

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The 2023 wildfire season in Quebec: an overview of extreme conditions, impacts, lessons learned and considerations for the future.

Y. Boulanger, D. Arseneault, A.-C. Belisle, Y. Bergeron, J. Boucher, Y. Boucher, V. Danneyrolles, S. Erni, P. Gachon, M. Girardin, E. Grant, P. Grondin, J.-P. Jette, G. Labadie, M. Leblond, , K. Waldron

The paper reviews the 2023 Quebec wildfire season, its extreme conditions, impacts on ecosystems and communities, and proposes strategies for future wildfire risk management.

bioRxiv · Feb 20, 2024Ecology

Massively parallel sample preparation for multiplexed single-cell proteomics using nPOP

A. Leduc, L. Koury, J. Cantlon, N. Slavov

The paper introduces nPOP, a method for preparing single-cell samples for multiplexed proteomics, achieving accurate quantification of thousands of proteins per cell.

bioRxiv · Nov 27, 2023Bioengineering

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

Z. Gao, M. Liu, A. P. Montalvo, Z. L. Gruskin, A. Leduc, Y. Xie, S. Preza, J. Du, X. Liu, V. Huhn, Z. Cheng, C. Krapp, M. Haemmerle, A. V. Rozo, X. Wen, , J. R. Alvarez-Dominguez

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

bioRxiv · Aug 11, 2023 · PreprintCell Biology

Slice-PASEF: Maximising Ion Utilisation in LC-MS Proteomics

L. R. Sinn, L. Szyrwiel, J. Grossmann, K. Lau, K. Faisst, D. Qin, F. Mutschler, L. Khoury, A. Leduc, M. Ralser, F. Coscia, M. Selbach, N. Slavov, N. Nagaraj, M. Steger, V. Demichev

Slice-PASEF improves tandem MS sensitivity for low-sample proteomics, enabling applications like single-cell proteomics and drug screens.

bioRxiv · Oct 31, 2022 · PreprintBiochemistry

Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages

R. G. Huffman, A. Leduc, C. Wichmann, M. di Gioia, F. Borriello, H. Specht, J. Derks, S. Khan, L. Khoury, E. Emmott, A. A. Petelski, D. H. Perlman, J. Cox, I. Zanoni, N. Slavov

The paper introduces pSCoPE, a single-cell proteomics method that improves sensitivity, completeness, and depth, enabling analysis of protein variation in macrophages.

bioRxiv · Mar 16, 2022Immunology

Multiplexed single-cell proteomics using SCoPE2

A. A. Petelski, E. Emmott, A. Leduc, R. G. Huffman, H. Specht, D. H. Perlman, N. Slavov

The paper introduces SCoPE2, a multiplexed single-cell proteomics method that enables quantitative analysis of over 1,000 proteins per cell using standard equipment.

bioRxiv · Mar 12, 2021Bioengineering