Panton-Valentine leukocidin-induced neutrophil extracellular traps lack antimicrobial activity and are readily induced in patients with recurrent PVL+-Staphylococcus aureus infections
H. Jhelum, D. Cerina, C. J. Harbort, A. Lindner, L. G. Hanitsch, R. Leistner, J.-T. Schröder, H. von Bernuth, M. S. Stegemann, M. Schürmann, A. Zychlinsky, R. Krüger, G. Marsman
This study shows that PVL-induced neutrophil extracellular traps (NETs) lack antimicrobial activity and that patients with recurrent PVL-SA infections have neutrophils more susceptible to PVL-induced NET formation.
bioRxiv · Nov 26, 2021Immunology