Author

J. Hein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:phylogenetics / evolution· 2 Approach:statistical model· 2 Organism:virus· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Ignatieva· 3 shared A. Kettenbach· 2 shared J. Nilsson· 2 shared P. A. Jenkins· 2 shared A. A. Jeyaprakash· 1 shared B. Lopez-Mendez· 1 shared B. McEwan· 1 shared C. Chan· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersEvolutionary Biology

A. Ignatieva

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Author profile →

5 papers

Recent·Most cited

Substrate recognition principles for the PP2A-B55 protein phosphatase

T. Kruse, D. Garvanska, J. K. Varga, W. Garland, B. McEwan, J. Hein, M. B. Weisser, I. B. Puy, C. Chan, P. S. Parrila, B. Lopez-Mendez, A. A. Jeyaprakash, O. Schueler-Furman, T. H. Jensen, A. Kettenbach, J. Nilsson

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

bioRxiv · Feb 10, 2024Cell Biology

KwARG: Parsimonious reconstruction of ancestral recombination graphs with recurrent mutation

A. Ignatieva, R. B. Lyngso, P. A. Jenkins, J. Hein

KwARG reconstructs ancestral recombination graphs using a parsimony-based greedy algorithm to minimize recombination and mutation events in genetic datasets.

Bioinformatics · Oct 11, 2021Peer-reviewedEvolutionary Biology

Recoverability of Ancestral Recombination Graph Topologies

E. Hayman, A. Ignatieva, J. Hein

The paper investigates the probability of accurately reconstructing ancestral recombination graph topologies under the coalescent with recombination and gene conversion, finding low accuracy for SARS-CoV-2-like parameters.

bioRxiv · Oct 10, 2021Evolutionary Biology

Ongoing recombination in SARS-CoV-2 revealed through genealogical reconstruction

A. Ignatieva, J. Hein, P. A. Jenkins

This study identifies ongoing recombination in SARS-CoV-2 using genealogical reconstruction and statistical analysis of sequencing data from England and South Africa.

bioRxiv · Jan 21, 2021Evolutionary Biology

Coupling of Cdc20 inhibition and activation by BubR1

J. Hein, D. H. Garvanska, I. Nasa, A. Kettenbach, J. Nilsson

This study shows BubR1 has both inhibitory and activating roles in Cdc20, enabling dephosphorylation by PP2A-B56 in the MCC while preventing premature anaphase.

bioRxiv · Dec 18, 2020Cell Biology