C. Chan

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.

Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes

This paper shows that immune checkpoint blockade (ICB) can delay cancer onset and improve survival in mice with mutator syndromes, but only if administered prophylactically before tumors develop.

Assessing the impact of autologous neutralizing antibodies on rebound dynamics in postnatally SHIV-infected ART-treated infant Rhesus macaques

This study examines how early ART initiation in HIV-infected infants affects antibody development and latent reservoir dynamics, showing their opposing impacts on post-treatment viral rebound.

RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

Comparative Analysis of Within-Host Dynamics of Acute Infection and Viral Rebound Dynamics in Postnatally SHIV-Infected ART-Treated Infant Rhesus Macaques

This study compares acute infection and viral rebound dynamics in ART-treated infant rhesus macaques using a mathematical model to identify increased infected cell death during rebound.

Altruistic feeding and cell-cell signaling during bacterial differentiation actively enhance phenotypic heterogeneity

This study shows that bacterial differentiation through altruistic feeding and cell-cell signaling increases phenotypic heterogeneity, enhancing population resilience to environmental changes.

Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

Substrate recognition principles for the PP2A-B55 protein phosphatase

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

Dengue virus exploits the host tRNA epitranscriptome to promote viral replication

This study shows dengue virus exploits host tRNA modifications to enhance viral replication by altering translation of pro-viral proteins.

Assessing The Impact Of Autologous Neutralizing Antibodies On Viral Rebound In Postnatally SHIV-Infected ART-Treated Infant Rhesus Macaques

This study investigates how the timing of ART initiation affects viral rebound in infant SHIV-infected Rhesus macaques, finding that latent reservoir size and high-potency neutralizing antibodies influence rebound time.

The mitochondrial calcium uniporter transports Ca2+ via a ligand-relay mechanism.

This study identifies a ligand-relay mechanism in the mitochondrial calcium uniporter (mtCU) driven by structural fluctuations in the DxxE sequence.

The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques

The study shows that deleting the pentameric complex in rhesus CMV does not affect congenital transmission in seronegative pregnant rhesus macaques.

ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes

This study uses human heart organoids to show that pregestational diabetes causes ER stress and lipid imbalance, leading to cardiomyopathy, and identifies potential therapeutic targets.

An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing

This study builds an isoform-resolution transcriptomic atlas of colorectal cancer using long-read single-cell sequencing and identifies neoepitopes for vaccine development.

Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model

This study investigates maternal cytomegalovirus (CMV) antibody responses and viral load in rhesus macaques to determine their association with vertical transmission risk, finding no link between plasma viremia or humoral responses and congenital CMV in immunocompetent dams.

Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody Responses

This study evaluates multivalent HCMV gB mRNA vaccines in rabbits, finding increased T cell responses but no improvement in antibody breadth.

An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

The paper identifies an RNA modification enzyme in Enterococcus faecalis that senses reactive oxygen species and regulates translation of stress-response proteins.

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

Mathematical Modeling of Rhesus Cytomegalovirus (RhCMV) Placental Transmission in Seronegative Rhesus Macaques

The paper develops a mathematical model of RhCMV placental transmission in rhesus macaques to study factors affecting congenital CMV infection risk.

Fate-resolved gene regulatory signatures of individual B lymphocytes in the early stages of Epstein-Barr Virus infection

This paper uses single-cell transcriptomics and chromatin accessibility to model early EBV infection dynamics and identifies regulatory signatures in B lymphocytes.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

Ad26.COV2.S Prevents SARS-CoV-2 Induced Pathways of Inflammation and Thrombosis in Hamsters

This study shows that Ad26.COV2.S vaccine prevents SARS-CoV-2-induced inflammation and thrombosis in hamsters by reducing proinflammatory and prothrombotic pathways and restoring gene expression profiles to uninfected levels.

A flexible electronic strain sensor for the real-time monitoring of tumor regression

This paper introduces a flexible electronic strain sensor that continuously monitors tumor volume changes in real-time, validated in mouse models with lung cancer and B-cell lymphoma.

Genomic rearrangements have consequences for introgression breeding as revealed by genome assemblies of wild and cultivated lentil species

The paper develops genome assemblies of wild and cultivated lentil species to reveal structural rearrangements affecting introgression breeding.

A deep generative model of 3D single-cell organization

The paper introduces a deep generative model to integrate 3D single-cell fluorescent image data of subcellular structures, enabling structure imputation and quantification of spatial variation.

Iron oxidation by a fused cytochrome-porin common to diverse iron-oxidizing bacteria

This study confirms that Cyc2 from neutrophilic iron-oxidizers functions as an iron oxidase, with a unique fused cytochrome-porin structure and redox potential suitable for Fe2+ oxidation at neutral pH.

An integrative structural model of the full-length gp16 ATPase in bacteriophage phi29 DNA packaging motor

This study reports the crystal structure of gp16-CTD and simulations of the full-length gp16, revealing its role in dsDNA packaging through interactions with pRNA and dynamic domain interplay, refining the inchworm-revolution model.

Comparative analysis of RNA enrichment methods for preparation of Cryptococcus neoformans RNA sequencing libraries

This paper compares three RNA enrichment methods for RNA-Seq in Cryptococcus neoformans, finding that RNase H depletion outperforms others in rRNA removal and expression accuracy.

Mechanical mapping of mammalian follicle development using Brillouin microscopy

This study uses Brillouin microscopy to quantify mechanical properties of mouse ovarian tissues during follicle development, revealing distinct material properties and intra-follicular compartments.