Substrate recognition principles for the PP2A-B55 protein phosphatase
T. Kruse, D. Garvanska, J. K. Varga, W. Garland, B. McEwan, J. Hein, M. B. Weisser, I. B. Puy, C. Chan, P. S. Parrila, B. Lopez-Mendez, A. A. Jeyaprakash, O. Schueler-Furman, T. H. Jensen, A. Kettenbach, J. Nilsson
The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.
bioRxiv · Feb 10, 2024Cell Biology