PathologybioRxiv
Heme Attenuates Endogenous Opioid Levels in Leukocytes of HIV positive individuals with Chronic Widespread Pain
S. Aggarwal, J. J. DeBerry, I. Ahmad…·S. Matalon
This study shows that heme-induced ER stress in leukocytes of HIV-positive individuals with chronic widespread pain reduces β-endorphin levels, contributing to increased pain sensitivity.