Y. Wen

Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy

The paper shows that microbial-derived exerkines from exercise-trained mice prevent skeletal muscle atrophy in a hindlimb-immobilization model.

The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator That is Sufficient for Growth

This study maps the 24-hour molecular response to resistance exercise in human muscle, identifying MYC as a key regulator of hypertrophy and mRNA levels.

The Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy

This study identifies RBX2 as a key component of the CRL5 ubiquitin ligase that regulates mitophagy in cardiomyocytes independently of PARKIN, maintaining cardiac homeostasis.

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β; pro-inflammatory signaling

This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.

Endosome-ER Interactions Define a Cellular Energy Landscape to Guide Cargo Transport

The paper analyzes EGFR-endosome transport dynamics in living cells, revealing spatially regulated 2-state motion and proposing an ER-driven free-energy landscape model for cargo transport.

A single-cell atlas of the single versus multiple parous Hu Sheep ovary

This study constructs a single-cell atlas of Hu sheep ovaries comparing high-litter (HLS) and low-litter (LLS) sheep, identifying molecular differences in granulosa cells that affect reproductive outcomes.

An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood

This study develops an ex vivo model to study EV-blood cell interactions in whole blood from pig-tailed macaques, showing EVs preferentially associate with B cells.

A Quadrivalent mRNA immunization elicits potent immune responses against vaccinia and monkeypox viral antigens - a step closer to a broad orthopoxvirus vaccine

This study develops an mRNA vaccine encoding four vaccinia antigens that induces strong immune responses against vaccinia and monkeypox viruses, suggesting broad orthopoxvirus protection.

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

A point mutation in Chl biosynthesis gene Mg-chelatase I subunit influences on leaf color and metabolism in strawberry

This study identifies a point mutation in the CHLI gene of strawberry that affects leaf color and metabolism by reducing chlorophyll and flavonoid levels and altering light sensitivity.

One-Pot Endonucleolytically Exponentiated Rolling Circle Amplification by CRISPR-Cas12a Affords Sensitive, Expedited Isothermal Detection of MicroRNAs

This paper develops a one-pot CRISPR-Cas12a-based assay for sensitive miRNA detection, achieving performance comparable to RT-qPCR while simplifying the workflow.

Structural insights into the viral proteins binding by TRIM7 reveal a general C-terminal glutamine recognition mechanism

The paper identifies a C-terminal glutamine recognition mechanism by TRIM7 that targets viral proteins, revealing its role in antiviral defense against norovirus and SARS-CoV-2.

Combating the SARS-CoV-2 Omicron variant with non-Omicron neutralizing antibodies

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.

A deep CNN framework for neural drive estimation from HD-EMG across contraction intensities and joint angles

This paper introduces a deep CNN framework to estimate neural drive from HD-EMG across varying contraction intensities and joint angles, achieving high accuracy without retraining for new conditions.

A sensitive and specific genetically encodable biosensor for potassium ions

The paper describes the development of a genetically encoded fluorescent K+ biosensor, GINKO2, optimized for sensitivity and specificity in vivo across multiple species.

Profiling tumor immune microenvironment of non-small cell lung cancer using multiplex immunofluorescence

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

Genetic and Epigenetic Regulation of Skeletal Muscle Ribosome Biogenesis with Exercise

This study examines how exercise affects ribosome biogenesis in skeletal muscle by analyzing genetic and epigenetic factors like rDNA copy number and methylation.

Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer

This study identifies a structural motif in the SMN YG box essential for higher-order oligomerization, which is critical for viability and linked to SMA in animal models.

The role of cation diffusion facilitator CDF-1 in lipid metabolism in Caenorhabditis elegans

This study identifies CDF-1 and SUR-7 as regulators of lipid metabolism in C. elegans, linking zinc homeostasis to lipid accumulation via the SREBP-SCD pathway.

Ceftazidime Is a Potential Drug to Inhibit SARS-CoV-2 Infection In Vitro by Blocking Spike Protein-ACE2 Interaction

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

Probing apoptosis signaling proteins in single living cells for precision efficacy evaluation of anti-cancer drugs

This paper introduces scPISA, a single-cell assay for evaluating anti-cancer drug efficacy by analyzing apoptosis signaling proteins, showing improved precision over conventional methods.

Clinical Significance of C4d Deposition in Renal Tissues from Patients with Primary Sj&oumlgren's Syndrome--A Preliminary Study

This study examines C4d deposition in renal tissues of primary Sjögren's syndrome patients, finding higher serum creatinine levels in those with tubulointerstitial C4d positivity.

Identification, Genotyping, and Pathogenicity of Trichosporon spp. Isolated from Giant Pandas

This study identifies and genotypes Trichosporon species isolated from giant pandas, finding 11 species with varying pathogenicity and genotypes.

Hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

This study shows hemolysin facilitates cytosolic LPS sensing by liberating bacterial outer membrane vesicles, leading to inflammasome activation and gut inflammation.

Harnessing the Cross-talk between Tumor Cells and Tumor-associated Macrophages with a Nano-drug for modulation of Glioblastoma Immune Microenvironment

This study demonstrates that Nano-DOX-loaded TAM can reprogram GBM cells to an anti-GBM phenotype through DAMP emission, enhancing immune response and reducing tumor growth.

Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCFSlmb degron

The paper identifies SCFSlmb as a regulator of SMN protein stability through a degron, showing that self-oligomerization stabilizes SMN isoforms and mitigates SMA severity.