MicrobiologybioRxiv
Protease-independent production of poliovirus virus-like particles in Pichia pastoris: Implications for efficient vaccine development and insights into capsid assembly.
L. Sherry, J. J. Swanson, K. Grehan…·D. J. Rowlands
This study produces protease-independent poliovirus VLPs in Pichia pastoris, showing they maintain native antigenicity and thermostability, suggesting potential for improved vaccine development.
DOI 10.1128/spectrum.04300-22