Author

L. Sherry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:yeast· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

N. J. Stonehouse· 5 shared D. J. Rowlands· 4 shared K. Grehan· 4 shared C. Porta· 2 shared D. I. Stuart· 2 shared E. Decembre· 2 shared E. E. Fry· 2 shared J. Alzahrani· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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5 shared papersMicrobiology

N. J. Stonehouse

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Protease-independent production of poliovirus virus-like particles in Pichia pastoris: Implications for efficient vaccine development and insights into capsid assembly.

L. Sherry, J. J. Swanson, K. Grehan, H. Xu, M. Uchida, I. M. Jones, N. J. Stonehouse, D. J. Rowlands

This study produces protease-independent poliovirus VLPs in Pichia pastoris, showing they maintain native antigenicity and thermostability, suggesting potential for improved vaccine development.

bioRxiv · Sep 16, 2022Microbiology

Production and characterisation of stabilised PV-3 virus-like particles using Pichia pastoris

L. Sherry, K. Grehan, J. J. Swanson, M. W. Bahar, C. Porta, E. E. Fry, D. I. Stuart, D. Rowlands, N. J. Stonehouse

This paper produces and characterizes stabilized PV-3 virus-like particles using Pichia pastoris, showing improved thermostability and antigen ratio compared to wild-type PV-3.

bioRxiv · Sep 16, 2022Microbiology

A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation

M. W. Bahar, V. Nasta, H. Fox, L. Sherry, K. Grehan, C. Porta, A. J. Macadam, N. J. Stonehouse, D. J. Rowlands, E. E. Fry, D. I. Stuart

This study identifies a conserved glutathione binding site in poliovirus VLPs that can be targeted by antivirals and used to stabilize vaccines.

bioRxiv · Sep 8, 2022Biochemistry

VelcroVax: a bolt-on vaccine platform technology improves antibody titres against a viral glycoprotein in mice

N. J. Stonehouse, N. J. Kingston, K. Grehan, J. S. Snowden, M. Hassall, J. Alzahrani, G. C. Paesen, L. Sherry, C. R. Hayward, A. Roe, S. Stephen, D. C. Tomlinson, A. Zeltina, K. J. Doores, N. A. Ranson, , D. J. Rowlands

VelcroVax is a vaccine platform that enhances antibody titres against a viral glycoprotein in mice by combining a modified VLP with a SUMO-tagged antigen.

bioRxiv · Apr 22, 2022 · PreprintImmunology

Recurrent Vulvovaginal Candidiasis; a dynamic interkingdom biofilm disease of Candida and Lactobacillus

E. McKloud, L. Sherry, R. Kean, C. Delaney, S. Williams, R. Metcalfe, R. Thomas, C. Williams, G. Ramage

This study investigates RVVC by analyzing the vaginal microbiome and interactions between Candida and Lactobacillus, finding reduced L. crispatus and increased L. iners, and showing Lactobacillus inhibition of Candida biofilm formation.

bioRxiv · Feb 12, 2021Microbiology

Structural insight into Pichia pastoris fatty acid synthase

J. S. Snowden, J. Alzahrani, L. Sherry, M. Stacey, D. J. Rowlands, N. A. Ranson, N. J. Stonehouse

The paper determines the structure of P. pastoris fatty acid synthase using cryoEM, identifying structural differences from S. cerevisiae FAS and resolving the mobile ACP domain.

bioRxiv · Jan 27, 2021Microbiology

Adaptation to host cell environment during experimental evolution of Zika virus

V. Grass, E. Hardy, K. Kobert, S. R. Talemi, E. Decembre, C. Guy, P. V. Markov, A. Kohl, M. Paris, A. Böckmann, S. Munoz-Gonzalez, L. Sherry, T. Höfer, B. Boussau, M. Dreux

This study identifies genetic adaptations in Zika virus during experimental evolution in host cells, revealing increased infectivity and resistance to TLR3-induced restriction.

bioRxiv · Dec 28, 2020Microbiology

Antiviral Response by Plasmacytoid Dendritic Cells via Interferogenic Synapse with Infected Cells

S. Assil, S. Coleon, E. Decembre, L. Sherry, O. Allatif, B. Webster, M. Dreux

This study identifies an interferogenic synapse between plasmacytoid dendritic cells and infected cells, essential for antiviral response via localized IFN-I secretion.

bioRxiv · Jul 24, 2018Microbiology