Author

J. J. Wright

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:cryo-EM· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

J. Hirst· 2 shared A. C. Powers· 1 shared A. L. Hopkirk· 1 shared A. M. Esteves· 1 shared A. Varshney· 1 shared B. S. Ivanov· 1 shared C. Dai· 1 shared C. S. Pereira· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

J. Hirst

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Author profile →

4 papers

Recent·Most cited

Structural basis of a regulatory switch in mammalian complex I

D. N. Grba, J. J. Wright, Z. Yin, W. Fisher, J. Hirst

This study defines the structural basis of a regulatory switch in mammalian complex I by combining cryoEM structures with biochemical analysis, showing how conformational changes mediate deactivation during ischaemia.

Science · Jun 14, 2024Peer-reviewedBiochemistry

Cryo-EM structures reveal ubiquinone-10 binding to mitochondrial complex I and conformational transitions associated with Q-site occupancy

I. Chung, J. J. Wright, H. R. Bridges, B. S. Ivanov, O. Biner, C. S. Pereira, G. M. Arantes, J. Hirst

The paper presents cryo-EM structures of mitochondrial complex I with and without ubiquinone-10, revealing conformational changes associated with Q-site occupancy.

bioRxiv · Feb 11, 2022Biochemistry

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

J. T. Walker, D. C. Saunders, V. Rai, C. Dai, P. Orchard, A. L. Hopkirk, C. V. Reihsmann, Y. Tao, S. Fan, S. Shrestha, A. Varshney, J. J. Wright, Y. D. Pettway, C. Ventresca, S. Agarwala, , M. Brissova

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

bioRxiv · Dec 16, 2021Cell Biology

Functional basis of electron transport within photosynthetic complex I

K. H. Richardson, J. J. Wright, M. Simenas, J. Thiemann, A. M. Esteves, G. McGuire, W. K. Myers, J. J. Morton, M. Hippler, M. M. Nowaczyk, G. Hanke, M. M. Roessler

The paper determines the reduction potentials of iron-sulphur clusters in Photosynthetic Complex I using DEER, revealing its bioenergetics and mechanism.

bioRxiv · Mar 9, 2021Biophysics