S. Fan

Diversified global vegetable oil production can mitigate climate change and achieve socio-environmental co-benefits

This paper assesses the environmental and economic impacts of global vegetable oil production and shows that diversification can reduce emissions and increase farmer income.

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Force-Enhanced Sensitive Detection of New DNA-Interactive Agents from Microorganisms at the Single-Molecule Level

This paper introduces a single-molecule stretching assay to detect DNA-intercalating agents from microorganisms, identifying two strains and three compounds with anti-cancer activity.

Autoantibodies against eukaryotic translation elongation factor 1 delta (EEF1D) in two patients with autoimmune cerebellar ataxia

This study identifies anti-EEF1D autoantibodies in two patients with autoimmune cerebellar ataxia, suggesting their potential as a biomarker for diagnosis and recurrence prevention.

Extracting herbicide and antibiotic natural products from a plant-microbe interaction system

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification System

This study uses scRNA-seq to classify PCCs into metabolism-type and kinase-type based on molecular features and microenvironment characteristics, suggesting potential therapeutic strategies.

Energy Coupling and Stoichiometry of Zn2+/H+ Antiport by the Cation Diffusion Facilitator YiiP

This study investigates the structural and functional roles of Zn2+/H+ antiport in YiiP using cryo-EM, thermophoresis, and simulations, revealing a transport stoichiometry of 1 Zn2+ to 2-3 H+.

Dopamine promotes Klebsiella quasivariicola proliferation and inflammatory response in the presence of macrophages

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

Cataloguing and profiling of the gut virome in Chinese populations uncover extensive viral signatures across common diseases

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

Host network-based discovery of critical regulators of innate immunity, virus growth, and pathogenesis in influenza virus infection

The paper identifies novel innate immune regulators affecting influenza virus replication and pathogenesis through experimental validation of network model predictions.

Structure and function of diadenylate cyclase DacM from Mycoplasma ovipneumoniae

This study identifies and characterizes DacM, a diadenylate cyclase in Mycoplasma ovipneumoniae that produces c-di-AMP, and presents its crystal structures to inform drug design.

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

Suppression of B-Cell Activation by Human Cord Blood-Derived Stem Cells (CB-SC) through the Galectin-9-Dependent Cell Contact Mechanism

This study shows that human cord blood-derived stem cells suppress B-cell activation via a Gal-9-dependent cell contact mechanism and affect calcium levels and signaling pathways.

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

The gravitation-driven stress-reduced urothelial barrier in toad bladder urothelium

The paper investigates how gravitation stress affects the transmembrane potential in toad bladder urothelium, showing increased chloride channel activity and altered ion permeability.

Ras guanine nucleotide exchange factor RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

Methylation of KRAS at lysine 182 and 184 by SETD7 promotes KRAS degradation

This study shows that SETD7 methylates KRAS at lysine 182 and 184, promoting its degradation and suppressing RAS/MEK/ERK signaling, thereby acting as a tumor suppressor in NSCLC.

Zinc Dependent Conformational Changes in the Cation Diffusion Facilitator YiiP from S. oneidensis

This study examines how Zn2+ binding affects the conformational changes in YiiP from S. oneidensis using cryo-EM and molecular dynamics simulations, revealing an intermediate state and a hydrophobic gate closure mechanism.

Dextran sulfate sodium salt corrupted colonic crypts declined the smooth muscle tension in mouse large intestine

This study shows that DSS-induced colitis in mice damages colonic crypts, leading to reduced smooth muscle tension and impaired myogenic contractions.

Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

The paper identifies PF-3845 as a novel inhibitor of Mycobacterium tuberculosis PheRS, showing selectivity over human PheRS and potential as an antibiotic lead.

Integrative Analysis the characterization of peroxiredoxins in pan-cancer

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

Gastric metabolomics analysis supports H. pyloris catabolism of organic and amino acids in both the corpus and antrum

This study compares metabolomics profiles in mouse gastric corpus and antrum organoids and tissue, revealing distinct metabolic differences and H. pylori nutrient utilization patterns.

Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis

This study evaluates givinostat's efficacy in treating NASH by reducing inflammation and fibrosis in mouse models.

Immune Response Drives Outcomes in Prostate Cancer: Implications for Immunotherapy

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.