ImmunologybioRxiv
Sustained post-developmental T-bet expression is critical for the maintenance of type 1 innate lymphoid cells in vivo
J.-H. Schroeder, L. B. Roberts, K. Meissl…·G. M. Lord
This study shows that sustained T-bet expression is necessary for maintaining intestinal ILC1 in vivo, and ILC1 depletion protects against colitis, suggesting potential therapeutic targeting of T-bet for IBD treatment.
DOI 10.3389/fimmu.2021.760198