E. Read

Noxious stimulation induces self-protective behaviour in bumblebees

This study shows bumblebees groom noxiously-stimulated antennae more than other body parts or controls, indicating they may experience pain.

A locomotion-based assay to measure prepulse inhibition in zebrafish larvae

This study introduces a locomotion-based prepulse inhibition assay in zebrafish larvae, showing reduced PPI after MK-801 treatment.

Simulation of receptor triggering by kinetic segregation shows role of oligomers and close-contacts

The paper uses simulations to show that CD45 oligomerization and close-cell contacts reduce the time for its surface evacuation, which is critical for T cell receptor triggering.

Locally-correlated kinetics of post-replication DNA methylation reveals processivity and region-specificity in DNA methylation maintenance

The paper uses mathematical models and stochastic simulations to show that DNA methylation maintenance rates are locally correlated, revealing processivity and region-specificity in methyltransferase activity.

Sustained post-developmental T-bet expression is critical for the maintenance of type 1 innate lymphoid cells in vivo

This study shows that sustained T-bet expression is necessary for maintaining intestinal ILC1 in vivo, and ILC1 depletion protects against colitis, suggesting potential therapeutic targeting of T-bet for IBD treatment.

ILC1-derived TGFβ1 drives intestinal remodelling

The paper shows ILC1-derived TGFβ1 drives intestinal epithelial crypt expansion and extracellular matrix remodeling in co-cultured organoids.

Hydrodynamics of transient cell-cell contact: The role of membrane permeability and active protrusion length

This paper simulates cell-cell contact formation to show that thin-layer fluid dynamics slow receptor-ligand interactions, requiring active forces or high permeability to overcome.