Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import
M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive
The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.
bioRxiv · Nov 1, 2019 · PreprintCancer Biology