Author

V. Purohit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. D. Mesecar· 1 shared A. Iuga· 1 shared A. Ma· 1 shared A. R. Decker· 1 shared A. R. Rosales· 1 shared B. R. Stockwell· 1 shared C. A. Lyssiotis· 1 shared C. D. Critchelow· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. D. Mesecar

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2 papers

Recent·Most cited

pH dependent inhibition from ammonium ions in the Pseudomonas mevalonii HMG-CoA Reductase crystallization environment

V. Purohit, C. N. Steussy, A. R. Rosales, C. D. Critchelow, T. Schmidt, P. Helquist, O. Wiest, A. D. Mesecar, C. V. Stauffacher

The paper investigates pH-dependent inhibition of Pseudomonas mevalonii HMG-CoA reductase in its crystallization environment, attributing the inhibition to ammonium ions and showing their effect on enzymatic activity and intermediate formation.

bioRxiv · Jun 3, 2020 · PreprintBiochemistry

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

bioRxiv · Nov 1, 2019 · PreprintCancer Biology