Author

A. Iuga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K. P. Olive· 3 shared C. F. Palermo· 2 shared G. A. Manji· 2 shared H. C. Maurer· 2 shared I. Sagalovskiy· 2 shared M. A. Badgley· 2 shared S. A. Sastra· 2 shared A. Andren· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

K. P. Olive

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cytotoxic chemotherapy potentiates the immune response and efficacy of combination CXCR4/PD-1 inhibition in models of pancreatic ductal adenocarcinoma

A. G. Raufi, I. Pellicciotta, C. Palermo, S. Sastra, A. Chen, E. Alouani, C. Maurer, M. May, A. Iuga, R. Rabadan, K. P. Olive, G. A. Manji

This study shows that combining gemcitabine with CXCR4 inhibitors and anti-PD1 therapy improves immune response and survival in pancreatic cancer models.

bioRxiv · Dec 24, 2023 · PreprintCancer Biology

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

A. Curiel-Garcia, S. Holmstrom, C. Castillo, C. F. Palermo, S. A. Sastra, A. Andren, L. Tomassoni, Z. Li, T. LeLarge, I. Sagalovskiy, D. R. Ross, W. Wong, K. Shaw, J. Genkinger, H. Hibshoosh, , K. P. Olive

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

bioRxiv · Mar 19, 2023 · PreprintCancer Biology

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

bioRxiv · Nov 1, 2019 · PreprintCancer Biology