Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection
C. G. Weindel, X. Zhao, E. Martinez, S. L. Bell, K. J. Vail, A. K. Coleman, J. J. VanPortfliet, B. Zhao, C. Mabry, P. Li, P. West, J. Karpac, K. L. Patrick, R. O. Watson
This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.
bioRxiv · Nov 18, 2021 · PreprintImmunology