Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies
D. A. Lukow, E. L. Sausville, P. Suri, N. K. Chunduri, J. Leu, J. Kendall, Z. Wang, Z. Storchova, J. M. Sheltzer
This study shows that chromosomal instability accelerates cancer cell adaptation to anti-cancer therapies by enabling specific aneuploidy events that reduce drug sensitivity.
bioRxiv · Sep 25, 2020Cancer Biology